Neural Hardware

Mutual Inhibition

Neurons that inhibit each other alternately; creates the biological equivalent of a pendulum or clock.

Mutual Inhibition is a circuit motif where two (or more) neural populations inhibit each other. When one is active, it suppresses the other; when it fatigues or is inhibited, the other becomes active. This creates rhythmic alternation — the basis of Central Pattern Generators (CPGs) for locomotion.

Key Applications

  • Locomotion — left/right leg alternation in walking
  • Breathing — inspiratory vs. expiratory neuron pools
  • Sleep-wake — flip-flop switch between wake and sleep centers

In ONDA Life

The CPG article explains how mutual inhibition underlies autonomous rhythmic movement.