Biological Software

Serotonin

A neurotransmitter regulating mood, sleep, and appetite — 95% produced in the gut by the microbiome.

Serotonin (5-HT) is a key neurotransmitter that regulates mood, sleep, appetite, and social behavior. Remarkably, approximately 95% of the body's serotonin is produced in the gut—not the brain—by enterochromaffin cells and influenced by the microbiome.

Key Functions

  • Mood regulation — low serotonin linked to anxiety and depression
  • Sleep — precursor to melatonin
  • Gut-brain axis — gut-produced serotonin influences brain via the Vagus Nerve
  • Appetite — modulates satiety and food intake

In ONDA Life

A healthy microbiome and diverse fiber intake support serotonin production. The Gut-Brain Axis article covers protocols for optimizing your "Serotonin Factory."