The most weight-loss-focused CGM programme — Dexcom G7 plus an AI agent that pushes meal-by-meal recommendations.Best for users whose primary CGM goal is weight loss and who respond to AI coaching nudges.
Signos is the CGM programme built for weight loss rather than general biohacker insight. Hardware is Dexcom G7; the differentiator is an AI agent that watches glucose curves in real time and pushes meal-by-meal recommendations through the app. Insights focus on glucose spikes that drive insulin and weight gain, with strong food-logging and exercise-prompt integration. Less academic than Levels, more behaviourally directive.
How we tested: Evidence-based assessment — scored from Signos product documentation, Dexcom G7 validation literature, company-published outcome data and independent 2026 reviews. Not hands-on tested by ONDA.
Dexcom G7 — 10-day wear, 30-minute warm-up, the same hardware as Levels and Stelo. In an independent head-to-head study (Eichenlaub et al. 2025) the G7 and FreeStyle Libre 3 were similarly accurate. The “FDA-Cleared” badge on its site refers to the Signos glucose monitoring system (app plus sensor) for glucose monitoring, not to weight loss.
Insights and analysis quality
8.0
Strong on glucose-spike interpretation and meal scoring; weight-loss framing throughout. Less general-purpose than Levels.
Coaching and guidance
7.0
AI agent surfaces meal-by-meal nudges and exercise prompts in real time. No human RD by default; some plans include access.
App and integration UX
7.5
Polished app with food logging and exercise integration. Apple Health support; narrower third-party stack than Levels.
Programme flexibility and data access
6.5
Monthly or annual subscription; annual is locked. Pause supported. Raw data export available.
Value
6.5
$140–$160/month including sensors. Cheaper than Levels, more expensive than Stelo.
Pros
+Best AI-coaching loop in the category — real-time meal and exercise nudges
+Dexcom G7 hardware — same accuracy ceiling as Levels
+Weight-loss outcomes documented in company-published case data
+Cheaper than Levels with similar accuracy
Cons
−Weight-loss framing may not fit users who want general biohacker insight
−No human RD in the default plan
−Insight engine less academically deep than Levels
−Annual commitment locks the price
Price: $140 $140–$160/mo including Dexcom G7 sensors (as of 2026-05-21)
Where it leads
Signos is the CGM programme that picked a specific job — weight loss — and built around it. The Dexcom G7 sensor underneath is the same one Levels and Nutrisense ship, but the app is the difference: an AI agent watches glucose curves in real time and pushes meal-by-meal recommendations, exercise nudges and snack-stack suggestions through notifications. The framing is consistent: glucose spikes drive insulin, insulin drives fat storage, and the app helps you flatten the curves that matter.
What are the downsides of Signos?
That same focus is the limit. If you want general biohacker insight — flow-state glucose stability, fasting metabolic adaptation, post-workout recovery curves — Levels gives you a more open analytical frame. The default plan has no human coach; access to a registered dietitian is a separate tier. Annual commitment locks the price even if the programme stops fitting your goals.
Who should buy Signos?
Choose Signos if weight loss is the primary reason you are wearing a CGM and you respond well to in-app AI nudges. If you want a deeper general-purpose insight engine, Levels. If you want a human coach, Nutrisense. The hardware is the same in all three — pick on what sits above it.
Background reading
The metabolic biology these programmes surface — and the protocols the data unlocks.
Signos is worth it if weight loss is your main CGM goal and you respond to coaching nudges. It has the category's best AI-coaching loop with real-time meal and exercise prompts, runs on Dexcom G7 hardware, and costs less than Levels with similar accuracy. General biohackers may find the weight-loss framing too narrow.
How much does Signos cost?
Signos costs about $140 to $160 per month, including Dexcom G7 sensors. That is cheaper than Levels with similar accuracy. Note that an annual commitment locks the price, so check the plan terms carefully before signing up.
What are the downsides of Signos?
Signos's weight-loss framing may not suit users wanting general biohacker insight, and the default plan includes no human registered dietitian. Its insight engine is less academically deep than Levels, and an annual commitment locks the price, reducing flexibility if you want to stop early.
Signos vs Levels: which is better?
Choose Signos if weight loss is the goal and AI coaching nudges motivate you; it is cheaper than Levels on the same Dexcom G7 hardware. Choose Levels if you want deeper, more academic metabolic insight for general biohacking rather than a weight-loss programme.
