Quercetin and Fisetin are flavonoid polyphenols found in foods (onions, apples, strawberries) and supplements. They have shown senolytic activity in preclinical research — inducing apoptosis in senescent cells while sparing healthy cells, potentially by targeting Bcl-2 family pathways.
Key Points
- •High-dose protocols — senolytic effects may require doses above typical dietary intake
- •Cycling — often used in "hit and run" protocols: high dose for 2–3 days, then 30 days off
- •Combination — sometimes combined with other senolytics (e.g., dasatinib) in research
In ONDA Life
The Senolytic High-Dosing article covers quercetin/fisetin protocols.