SASP (Senescence-Associated Secretory Phenotype) is the mix of inflammatory cytokines, chemokines, proteases, and other factors secreted by senescent cells. It damages surrounding tissue, promotes chronic inflammation, and drives aging phenotypes.
Key Components
- •IL-6, IL-8 — pro-inflammatory cytokines
- •MMPs — matrix metalloproteinases that degrade tissue
- •Spread — SASP can induce senescence in neighboring cells
In ONDA Life
The Senolytic article covers protocols to reduce SASP burden by clearing senescent cells.