Senescence is a state in which a cell stops dividing (permanent growth arrest) but remains alive and metabolically active. Senescent cells often secrete pro-inflammatory factors (the SASP) that damage neighboring cells and drive aging.
Key Concepts
- •SASP — Senescence-Associated Secretory Phenotype; cytokine/protease "cocktail"
- •Zombie cells — accumulate with age, driving chronic inflammation
- •Senolytics — compounds that selectively eliminate senescent cells
- •Apoptosis — programmed cell death; senolytics induce it in senescent cells
In ONDA Life
The Senolytic High-Dosing article covers quercetin/fisetin and other senolytic protocols.