The short version
The Coway Airmega 400 is the large-room value champion; the IQAir HealthPro Plus is the clinical reference — HyperHEPA H14 medical-grade filtration at more than double the price.
When the Coway Airmega 400 is the right pick
You want verified large-room HEPA filtration at strong value, without paying for clinical-grade capture.
When the IQAir HealthPro Plus is the right pick
You need the deepest filtration — allergies, VOCs, chemical sensitivity or medical-grade reassurance.
Also worth comparing
See Coway Airmega 400 vs Dyson Big+Quiet and Dyson vs IQAir. Full field: best air purifiers.